I guess... But you realise how long it would take a TB caravan to get from say NCR to vault city?
Combined with the fact that the encounters themselves would take much longer, increasing your chances of being ambushed.
Then there's the bugs and issues with TB, like what if an NPC gets stuck in a doorway and 5 players have to wait out the turns of a dozen NPCs, or someone starts a combat and refuses to end it.. Leaving 5 players in massive rage and one guy trolololing.