I always tought that new players should start with some NPC dialogue explaining him how harsh are the wastes, and not leaving it to wiki reading learning, cause we all know for a gammer the best way to lear is gamming
Such thing is already implemented and works for ages on FOnline2. New character starts in a tent of Kenny, NPC that stops him to tell things or two. I'm not sure how many, it's been a while since I've checked it myself. You can also gain a level without even leaving the place. Surprisingly many players hits Esc key and leaves the location, ignoring the dialogues, explanations, harshness and stuff, then they moan because nobody told them where to get professions or something. You cannot force anyone to do what he or she doesn't want to in a computer game, especially sandbox type one.
Also Junktown as a noobville with quests and pre-fire AI guards exists on FO2 since the beginning. Result? Trolls, gankers and griefers wandering around the city, searching for 80 HP characters to mutilate and piss on, then masturbate over so called "PvP screens" with a slice of lemon in mouth and a foil bag on the head. Every cunt and his dog knows FO2 Junktown area is the best place to, well, farm frags on newcomers.
There was some effort made to fix this sick situation - an NPC faction involving players willing to babysit newbies, called Junktown Scouts. Didn't change much since this is hard, time consuming job barely anyone appreciates. I've been doing this for years on 2238, couldn't be bothered anymore on FO2 or Reloaded. You don't get XP for staying in town and explaining someone how to set up a tent or do quests, so your own character stays on low levels with miserable or no gear at all. Giving these good people any equipment out or level by GM ends up same as always - with crying and drama over pixels and shit. And, last but not least, when someone stubborn enough takes newcomers for a tour with his undeveloped character and poor gun, they encounter a brave frag hunter, who didn't waste his precious time for explanations or wiping someone's nose but leveled up, gathered pixels and now can smash them carebears and noobs, woohoo, well done, letters X and D all over, eat dust n00b and lrn2play, yadda yadda. Why new players are not coming back afterwards? That's a mystery.
Solution I've figured out way too late to fix anything is not widely acceptable I'm afraid. Dedicated NPC faction (Junktown Scouts, Followers of Apocalypse, whatever) run by GM with few mature blokes from different time zones hired as full time nurses to take care of newcomers. To save everyone's time characters of these people should be leveled up using GM panel (it's a matter of changing one parameter of character - current XP, used to take me like 10 minutes or so to level up a character from the scratch to 24th level and 20 minutes if dude wasn't sure about perks and stuff) or some similar way. To save everyone's even more time gear should be given away by same GM (but not like T3/T4 shit, get real). To save newcomers from ragequits and keep them around the game, patrols consisting of said characters and newcomers should be organized on a regular basis, to get rid of all the ganking-griefing scum around and prove that you can do something in this game other than being a meatshield or a rag doll. This has been tested on FO2 by my mates and worked great as Hub Mercenaries project, but turned out to be GM abuse when they've won a battle or two ganking some gankers. So I feel like I've done my bit and won't abuse anymore, fear not.
Or just make it simple and automate all the starting process by giving out 24 lvl to every new character created. Still pixels need to be gathered, so there's still something to do in game. But it's not a natural way of making progress in game and why bother doing any quests then? Screw all that, let's shoot each other, yay! Fallout spirit? Never heard of it, is this some sort of alcohol?
NPC factions should offer a lot more privileges... when time comes, the player will want to make his own faction to play along the guys he meet at npc factions, its natural. And if he decides to stay, would be cool to see some BoS guys against Enclave guys and letting them also make town control.
NPC faction needs a dedicated GM to keep it running and as experience shows, it's all about free items or pixels in general in the end of the day. And abuse accusations, every fucking time faction X wins with Y or something.
And speaking of NPC factions - this whole idea of player driven factions, TC and banana boxes should be, in my personal opinion, slowly but consequently abandoned and forgotten. Organized groups are still around? Great, choose between Enclave, BoS, Raiders, Hub Watermerchants, Master's Army, whatever fits the lore, then gather, arm and win for glory and lulz. Preferably in designated locations other than towns (that finally could be populated), clearly marked "you'll get your pale ass chewed if you enter here, come only if you dare", so everyone gets the message.