I like Vehemence's build. It looks well balanced and easy to level and should be very good for crafting purposes.
However, Jish's sneak suggestion got me thinking if sneak capability could be combined with Vehemance's build. This is what I came up with. This build should be able to handle most PvE fights easily, although it does not have as many hit points as Vehemance's build and is weak against criticals. On the plus side, carry weight is good and it can have all the professions. I left Science skill to 120%, because that is what you need for Dismantler perk since as far as I know, Science skill does not affect on the amount of resources you get from dismantled items.
http://www.fonline-reloaded.net/wiki/index.php?title=Dismantling Getting the sneak skill to 300% will require some leveling though, but it shouldn't be too much work. With high Sneak skill you should be able to go to advanced workbenches undetected and this is why I picked the Silent running perk. Later on you should also boost Outdoorsman skill to max for faster travel speed, a few support perks and being able to avoid unwanted encounters.
Some things to consider and keep in mind:
-You can have slaves to mine resources for you, but if you are not going to be a slaver, you can take loner trait to level even faster.
-Have another character to deliver you 10 science books right when you start, so you can increase your science skill to 100% in order to get Educated perk at level 2.
-Using drugs is optional. Nuka, cigs and buffout can be helpful in combat and crafting runs, but are not a necessity. Mentats can be used to get even more slaves if you did not choose the Loner trait.