I've decided to help players like me who are new in game and are actually doing something to learn basics on their own.
From zero to hero, how to level up in short.
1. Progenitor (1st) character design (no books at start, no support of any kind from other characters)
Stats: STR 7, PE 4, END 10, CHA 1, INT 6, AGI 10, LK 2
Traits: Fast Shoot, Looner
Tagged skils: Small Guns, First Aid, Outdoorsman
Skill development: 200 Small Guns->125 First Aid->125 Doctor ->170 First Aid ->125 Repair ->200 First Aid ->150 Outdoorsman
Perks: Adrenaline Rush[4]-> Even More Criticals[6]-> Bonus Ranged Damage[9] ->Action Boy[12] -> Action Boy[15] ->Bonus Rate of Fire[18] ->More Ranged Damage[21] ->Medic[24]
[Hint]If for some reason You can't pick desired perk You can delay it for 2 more levels to get sufficient skill points to unlock it.
2. Preparations
1st of all it is imperative to get Multitool and Hatchet. If You didn't get those from starting area You can find Caravan Packer in Hub, take a job from it and earn 250caps by moving 10 crates inside shack near kid named Shren. Do it 2-3 times, move along road (SE) and check NPCs in Shops at the road end for Multitool and Hatchet. Once You get those equip them in both slots. When Multitool is equipped in slot 1 You can scavenge items, with Hatchet in Slot 1 You can chop wood. For now move to Old Town with Multitool active (If You see a Apple Tree on the way pick up all apples from it, do it every time You see apple tree near You). Do some scavenging. Try to get some electronic parts from Broken computer (use science skill on it). Press fix button and turn all junk parts into Brass Knuckles. Turn all electronic parts, alloys and metal parts to NPC named Ferrarius (exp and caps, You have to have specified bulk quantity to turn them in). Exit Old Town and for next 10mins or so try to find all Apple Trees (3 total), and 2 Stills (one in Tent, E part and one in Broken building in W part). Try out to chop some wood (half of the amount of apples You have in inventory). Go to one of the Stills, put all apples and wood inside, use Science skill on it and wait until it stops to do "puff" etc. Pick up Rotgut. Now find Beth in Guns shop, she pays quite nice caps for one bottle. Do not limit Yourself to scavenging only in Old Town, do it in entire Hub and don't forget about making Rotgut from apples and wood. Stay in Hub until You get around 20k caps.
3. Check if You can make a tent. If not You will have to complete a quest for it (look for more info at wiki). Once You can make tents head back to Hub. Buy or make a gun (I recommend combat shotgun, it will be usefull later) along with ammo (50 rounds will be enough). Make 4 tents (brahmin hides can be bought from Claire NPC in Old Town). Exit Hub, place 1 tent as close as possible to Hub. Once done head SW to Boneyard until You see Boneyard Train Station. Buy a ticket and use train to get to San Francisco. Place another tent as close as possible to San Francisco (preferably between train station and city). Use train to get back to Boneyard Train station and NCR Train Station. Head NW from NCR (target grid 27:17, You can see coordinates on word map when You move cursor around it) until You find Broken Hills. Place Your 3rd tent as close as possible to it too. Once done head west until You find New Reno (it will be tricky part, read hint below). Enter it, head NW along the road, take right turn at Shark Club crossroads, at the end there are 2 exit grids, take northern one, look for T-Ray NPC. Talk to him and buy Buggy (15k caps, plus like 1k more for Rotgut engine upgrade). Congratulations for buying Your 1st vehicle...now enter it and move NW again (do not place tent near New Reno yet). Find Den at coords 10:5. Place last tent here- You don't have to leave vehicle in city or random location near it. It will be moved to Your tent after it is created. Enter vehicle and get back to Your tent near Hub, leave vehicle there and move character to Hub square (do not enter it yet). Press little red button to the left from Town/World words. You can choose now Your arrival point in Hub, select Water Merchant District.
Hint: Do not fight at random encounters. Just move ASAP to closest exit grid (just make sure You are moving away from hostile NPCs at the same time too).
4. Leveling up to ~lvl 28
In Water Merchant District look for a short guy named Mere, talk to him and agree to his proposal. Take 3 barrels at once. If You can't move drop some junk on the ground. Exit Water Merchants District, to he left there will be red exit grid, use it. Move to Your Hub tent, drop all unnecessary items inside tents Shelf or Chest. Enter Vehicle go to San Francisco tent, leave vehicle there and deliver one water crate to Lao Chou (follow road, 1st building to the left. Get back to Vehicle and move to Den tent. Deliver 2nd crate to Frankie (owner of the pub The Hole, it has heart sign on it). 3rd delivery goes to Marcus in Broken Hills. Once done get back to Hub for Your reward...and another run. Repeat this process until You get First Aid skill around 180 and repair skill at 125. Use part of the reward money to buy some books of science until You get science at 50. Talk to Mrs. Stapleton in Hub library to get Swift Learner perk. Then slowly buy 10 books "Dean's Electronics" to boost repair skill.
Hint nr 1: Never ever park vehicle in random location or city. It might get stolen. You can get out of forced random encounter easily if You click vehicle ASAP once map loads.
Hint nr 2: At lvl 6 You can get Strong Back (Francis in Broken Hills) and Pack Rat (Dangerous Dan McGrew in Redding) to boost Your carrying capacity permanently.
5. Leveling up to 50 (or more if You are patient).
Preparations: Visit Barter Grounds (grid 19:10), look for NPC named Lonestar Collection Agency, join it (it might require donation of 10k caps, pay it if necessary). Return to Hub, make another tent, buy combat armor and combat helmet. Make sure You have Mr. Fixit Perk (NPC Smitty, Den west side). Buy some shotgun shells too (around 200 for a start). Head to Junktown, place tent near it and enter town. Look for Boyce NPC, learn Gunsmith profession from Boyce. Talk to Junktown Scout Leader NPC- You will find out that he pays for leather armor, leather caps in bulk of 6 each (that gives exp too) and more. On the western side tent there is NPC Scout Captain Lex, talk to him and agree to do bounty quest for killing Vipers gang. Exit town, go to Vipers location and be prepared to see Your hp coming down from 200 to ~120 right on the start. Do not worry about it, use First Aid Skill to heal Yourself (do not move yet), target Vipers with shotgun 1st (those close to each other are priority, You should have APs for 1 burst left for combat shotgun), w8 until timer goes down to 0 and allow melee Vipers to come at You, they will work as a shield vs ranged ones. At the beginning of next round use 2 free movement point to move away from melee Vipers a bit just to have clear line of fire at ranged Vipers. Burst them when there is around 4 secs of the round left. This way at the end of 2nd turn or at the beginning of 3rd one You will be able to use First Aid skill again (usually full hp). When ranged Vipers are down proceed with finishing melee ones (take 1 step away and burst, burst...). When all Vipers are down loot everything except shotguns (I have not found bulk order jobs for those...). Return to Junktown. Repeat. When You are almost overloaded with loot, talk to scout leader, turn in all leather caps and armor for caps and exp. In case You get more ammo than You need just drop it in tents Shelf or Chest.
Some things to remember about:
1. Fix armor/weapon when it is around 70% condition (equip Super Toolkit in Slot 1, then use repair skill on armor and weapon). Super tool kit costs 2k and can be bought from Rondo in NCR.
2. Every 20 bounty hunter missions done= 1 random blueprint (You can get combat armor blueprint that way too).
3. Sometimes You will receive heavy critical, will be knocked down and miss 2 turns, this can be deadly but also can be avoided by taking Stonewall and Quick Recovery perks. Personally I believe it doesn't happen often enough to sacrifice Action Boy Perks (or other ones) to get them.
4. Explorer and Pathfinder perks make You travel faster (so less time is wasted on travel) and in the end lvl up faster too.
5. You can use vehicle as a shield too (this might reduce chances of getting killed in 1st turn drastically), especially at start when Outdoorsman skill is low.
6. If location name has "City" in it there is a chance to get Fuel Cell controller from it (look for a car without roof and engine cover with visible engine parts).
7. If location name has "Desert Tree" there is VERY high chance of getting Apple Tree in it too (Rotgut is nice shopfood or fuel for Your car with Rotgut engine upgrade).
8. Combat Knife in bulk of 8 can be exchanged for caps and exp at Eirnhart NPC in New Audytum.
P.S. If You know bulk order job for shotguns please post it here too.