One change for Unarmed/Melee character would be that taking drugs to boost agility should let use have access to more advanced kicks and punches. Such as Strong Punch, Hammer Punch, Haymaker, Jab, Piercing Strike, Strong Kick, Snap Kick, Power Kick, Hip Kick, Hook and Piercing Kick.
Also how about changing Between the Gaps to 90% or something like that when you get 300% in unarmed/melee.